This is often due to a prolonged intake of Estrogen. The risk will vary on the length of the treatment and the dosage of the Estrogen taken by a patient. Since Estrogen therapy has the long term and the short term period, it must be noted that lower dose of medicine should be taken for the long term in order to reduce the risk. Other doctors prescribe it for people who have low levels of Estrogen. However, the dosage that a person should apply always depends on the doctor s recommendation. Each of the patches is sealed individually in a protective pouch. You can also apply this directly to the skin though some patches require a base medicine. Estrogen may also increase a risk of blood clotting, which can damage the proper circulation in the arteries. Significant proof suggests that long-term use of estrogen can slowly increase the risk of breast cancer. In addition, researches have also shown that there is a greater risk of breast cancer among women who use both the estrogen and the progestin. Estrogen replacement therapy replaces the hormones that are no longer produced by the ovary. It also provides relief for the unpleasant risks and effects that are brought by the symptoms of menopause in a woman s body specifically the hot flashes and the night sweat. Aside from merely using estrogen it is also sometimes associated with progestin. Estrogen cream has a very rich history in the field of dermatological products and is really proven effective in curing hormonal and vaginal disorder. However, it was also found out that its excessive use can increase the risk of malignant melanoma and other cancerous diseases. Bear this in your mind that before you decided to use Estrogen cream in treating estrogen imbalance you need to go to your doctor first and undergo initial check of your condition to avoid unnecessary side effects. Many studies and researches were conducted towards finding out the very nature of estrogen. All of these undertakings agreed on one thing, estrogen is a primary component in the indication of the human body clock. It was found that it directly relates in the body cycle of a human being. Estrogen, as defined in the modern medical dictionary- does not only pertain to a single compound but is rather made up of groups of steroid compounds.