Estrogen may also increase a risk of blood clotting, which can damage the proper circulation in the arteries. Significant proof suggests that long-term use of estrogen can slowly increase the risk of breast cancer. In addition, researches have also shown that there is a greater risk of breast cancer among women who use both the estrogen and the progestin. The use of conjugated estrogens is usually known for significant drop in the occurrence of heart disease and osteoporosis, including a decrease of approximately 10% in the incidence of heart disease and stroke, over non-estrogen users. The levels of PA-1 are discovered to plunge down by around 50% when an intake of Conjugated estrogens is done with or without the presence of progestins. This is the main estrogen being produced in the ovary. 2. Estratiol this is the most common estrogen. It is adapted to estrone. This is the most powerful estrogen produced by the ovary before menopausal stage. 3. Estriol - this is the least powerful among the three. Since these estrogen hormones can be taken, they have the same effects and side effects especially if the doses are the same. Among the most common supplement for the Estrogen that achieves hormonal balance is the Premarin. This comes from the urine of a pregnant mare that contains various types of Estrogen. But only half of the Estrogens content in Premarin is found in human beings. If Premarin is not suited in a person s system, it will result to the following side effects: A person experiences bloating and swelling in some areas of the body that may seem very unusual. This is the necessity of having an appropriate level of Estrogen to prevent the unnecessary disorders that may take place inside a woman s body. Moreover, if the level of hormone is also imbalanced the risks of the menopausal symptoms will increase. It is true that Estrogen is a natural body substance but it is coupled with side effects in the person s body. In the case of those who take Estraderm, Vivelle, Climera the finding suggests that .02 to .05 mg/ day be taken when transdermal preparation is used, while the Menostar estrogen brand has the lowest dosage with the required daily intake of only .014 mg/ day. Since the matter of decision-making is relatively dependent on individual basis, rather than taking into consideration age groups and related cases.