The levels of PA-1 are discovered to plunge down by around 50% when an intake of Conjugated estrogens is done with or without the presence of progestins. PA-1 is said to be the vital inhibitor of fibrinolysis which multiplies in women after menopause and may risk a lady s life of cardiovascular disease. Among the most common supplement for the Estrogen that achieves hormonal balance is the Premarin. This comes from the urine of a pregnant mare that contains various types of Estrogen. But only half of the Estrogens content in Premarin is found in human beings. If Premarin is not suited in a person s system, it will result to the following side effects: A person experiences bloating and swelling in some areas of the body that may seem very unusual. Hormone replacement therapy these is a method used to supply the needed amount of estrogen in the body. It regulates the amount of estrogen to normal in the body so it will function effectively. Estrogen supplements - these are drugs that are taken orally to maintain the normal estrogen level in the body. The Effects of Low Estrogen Production in the Body As the women grow older, the production of estrogen decreases resulting to the last stage of menstruation, which is better known as menopause. Estrogen is the main hormone responsible for the cessation of menstruation. Many studies have proven that low production of estrogen in the body causes the permanent absence of menstruation. These two disease both need immediate treatment. Though the first disease will is not a killer disease, it can also make your life difficult to lead on. The latter one is a dreaded disease that might kill a patient when not properly treated. As for conclusion, in order to avoid such diseases, it is important that women with estrogen deficiency should be given ample care. Most women still use estrogen pills perhaps: Have not heard anything about the life-threatening danger it could give. These women have no idea of what is happening around them. Perhaps, she did not even know that such report exists. Simply do not care at all. This may be the same as the first situation.